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Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
Published on: December 1, 2023
Long noncoding RNA DANCR in various cancers: a meta-analysis and bioinformatics
Lihong Wang1, Yalin Xie2, Hui Fang1
1Department of Geratology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, People's Republic of China.
Differentiation antagonizing non-protein-coding RNA (DANCR) is a novel biomarker. High DANCR expression indicates poor cancer survival and advanced tumor stages, suggesting its potential as a prognostic indicator.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Differentiation antagonizing non-protein-coding RNA (DANCR) is a newly identified long noncoding RNA.
- Aberrant DANCR expression is observed in various cancers, correlating with adverse outcomes.
- The clinical diagnostic value of DANCR in tumors requires further elucidation.
Purpose of the Study:
- To evaluate the clinical diagnostic significance of DANCR in cancer.
- To assess the association between DANCR expression and patient prognosis.
- To determine DANCR's utility as a prognostic biomarker.
Main Methods:
- A comprehensive literature search was conducted across multiple databases up to December 2018.
- A meta-analysis included 11 studies encompassing 945 cancer patients.
- Results were validated using The Cancer Genome Atlas (TCGA) dataset.
Main Results:
- Elevated DANCR expression significantly predicted poorer overall survival (HR=0.56, P=0.000), confirmed by TCGA data.
- DANCR expression correlated with advanced tumor node metastasis (TNM) stage (OR=0.22, P=0.001).
- High DANCR levels were associated with lymph node metastasis (OR=0.21, P=0.001).
Conclusions:
- Increased DANCR expression is linked to unfavorable clinical outcomes in cancer patients.
- DANCR demonstrates potential as a valuable prognostic biomarker for cancer.
- Further research can explore DANCR's role in cancer progression and therapeutic strategies.
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