Related Experiment Video
Updated: Jan 20, 2026
09:19
Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
Published on: December 9, 2014
26.2K
CD36 tango in cancer: signaling pathways and functions
1Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.
Theranostics
|August 15, 2019
Summary
CD36, a scavenger receptor, plays a dual role in cancer by promoting metastasis and resistance while also potentially inhibiting tumor growth. Targeting CD36 offers a promising strategy for cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- CD36 is a scavenger receptor involved in lipid uptake, immune recognition, and inflammation.
- It binds to ligands like fatty acids (FAs) and thrombospondin-1 (TSP-1).
- CD36 influences tumor progression, metastasis, and therapy resistance through lipid metabolism.
Purpose of the Study:
- To provide a comprehensive overview of CD36 in cancer.
- To explore its structure, regulation, ligands, and functions.
- To discuss the potential of targeting CD36 for cancer therapy.
Main Methods:
- Literature review of CD36's role in cancer.
- Analysis of CD36's interactions with ligands and cellular pathways.
- Examination of CD36's impact on tumor microenvironment and immune cells.
Main Results:
- CD36 enhances tumor metastasis and therapy resistance via increased lipid uptake and FA oxidation.
- CD36 can attenuate angiogenesis by interacting with TSP-1.
- CD36 promotes immune tolerance in the tumor microenvironment.
Conclusions:
- CD36 exhibits complex roles in cancer, promoting certain aspects while inhibiting others.
- Understanding CD36's regulatory networks is key to developing targeted cancer therapies.
- CD36 represents a potential therapeutic target for various cancers.
Related Concept Videos
01:19Interactions Between Signaling Pathways
7.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.2K
03:14Notch Signaling Pathway
6.5K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.5K
02:33Hedgehog Signaling Pathway
9.8K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
9.8K
01:28Insulin: The Receptor and Signaling Pathways
2.8K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
2.8K
01:11IP3/DAG Signaling Pathway
14.3K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
14.3K
01:28Nitric Oxide Signaling Pathway
6.2K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.2K