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Updated: Jan 20, 2026

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
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Current promising treatment strategy for glioblastoma multiform: A review

Sanjib Bahadur1, Arvind Kumar Sahu1, Pragya Baghel1

  • 1Department of Pharmaceutics, Columbia Institute of Pharmacy, Near Vidhan Sabha, Raipur, Chhattisgarh, India.

Oncology Reviews
|August 15, 2019
PubMed

Insights

Glioblastoma multiform (GBM) is a deadly brain cancer resistant to temozolomide (TMZ). This review explores new pharmaceutical candidates to overcome TMZ resistance and improve survival for GBM patients.

Area of Science:

  • Neuro-oncology
  • Cancer pharmacology
  • Drug resistance mechanisms

Background:

  • Glioblastoma multiform (GBM) is an aggressive brain tumor with poor prognosis.
  • Current treatments including surgery, radiation, and chemotherapy have limited efficacy.
  • Temozolomide (TMZ) is the standard chemotherapy, but resistance often develops.

Purpose of the Study:

  • To review novel pharmaceutical candidates for GBM treatment.
  • To explore strategies to overcome temozolomide (TMZ) resistance.
  • To enhance the therapeutic efficacy of TMZ in glioblastoma.

Main Methods:

  • Literature review of recent advancements in GBM targeted therapy.
  • Analysis of drug resistance mechanisms involving O6-methylguanine-DNA methyltransferase (MGMT).
  • Identification of promising pharmaceutical agents and conjugated strategies.

Main Results:

  • Temozolomide resistance is a major challenge in GBM treatment.
  • Specific pharmaceutical candidates show potential in overcoming resistance.
  • Targeted therapy approaches can enhance TMZ efficacy.

Conclusions:

  • New pharmaceutical strategies are crucial for improving GBM outcomes.
  • Overcoming TMZ resistance is key to enhancing patient survival.
  • Targeted therapies offer a promising avenue for future GBM treatment.
Keywords:
Glioblastomaresistancetargeted therapytemozolomide

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