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The ABCD database: a repository for chemically defined antibodies.

Wanessa C Lima1, Elisabeth Gasteiger2, Paolo Marcatili3

  • 1Geneva Antibody Facility, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.

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|August 15, 2019
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Summary
This summary is machine-generated.

The AntiBodies Chemically Defined (ABCD) database offers sequenced antibodies with antigen information to enhance research reproducibility. This free resource provides unique identifiers for antibodies, aiding in rapid availability checks for specific antigens.

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Area of Science:

  • Biochemistry
  • Immunology
  • Bioinformatics

Background:

  • Reproducibility in academic research is a significant challenge.
  • Antibody characterization and tracking are crucial for experimental consistency.
  • Lack of standardized antibody information hinders data sharing and validation.

Purpose of the Study:

  • To introduce the AntiBodies Chemically Defined (ABCD) database.
  • To provide a centralized repository for sequenced antibodies and associated antigen data.
  • To enhance reproducibility in antibody-based research.

Main Methods:

  • Integration of curated antibody sequence data.
  • Cross-linking to standardized chemical and protein entity databases.
  • Development of a unique, unambiguous identifier system for each antibody sequence.

Main Results:

  • The ABCD database provides a comprehensive collection of sequenced antibodies.
  • Each antibody entry includes curated information on the antibody and its antigen.
  • Unique identifiers facilitate unambiguous antibody tracking and retrieval.
  • The database enables rapid determination of antibody availability for specific antigens.

Conclusions:

  • The ABCD database serves as a valuable resource for the academic community.
  • It significantly contributes to improving reproducibility in scientific research.
  • The freely accessible platform (via ExPASy server) promotes data standardization and accessibility.