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Updated: Jan 20, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

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A pilot study of first-line olaratumab, doxorubicin and ifosfamide in patients with metastatic soft tissue sarcoma

Olga Vornicova1, Nissim Haim2,3, Gil Bar-Sela4,5

  • 1Cancer Center, Emek Medical Center, 21 Yitzhak Rabin Blvd, 1834111, Afula, Israel.

Cancer Chemotherapy and Pharmacology
|August 15, 2019
PubMed
Abstract

Insights

Adding olaratumab to doxorubicin and ifosfamide shows activity in metastatic soft tissue sarcoma. This combination demonstrates a comparable safety profile to standard doxorubicin and ifosfamide treatments for MSTS.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic soft tissue sarcoma (MSTS) is a challenging diagnosis.
  • Olaratumab (O), a PDGFRα-binding monoclonal antibody, is approved in combination with doxorubicin (D) for MSTS.
  • Doxorubicin plus ifosfamide (D+I) is a common MSTS treatment with a higher response rate than D alone.

Purpose of the Study:

  • To evaluate the preliminary efficacy and safety of combining olaratumab with doxorubicin and ifosfamide (ODI) in first-line MSTS treatment.

Main Methods:

  • A total of 15 MSTS patients received first-line ODI therapy between January 2015 and May 2018.
  • Two dosing regimens were used for D and I, with olaratumab administered intravenously on days 1 and 8 of each 21-day cycle.

Main Results:

  • Objective response rate was 27% (3 complete responses, 1 partial response) with a median overall survival of 22 months.
  • 33% of patients achieved stable disease for at least 5 months.
  • Grade 3-4 neutropenia occurred in 47% of patients, and 20% experienced neutropenic fever. Grade 3 diarrhea was observed in 13% of patients, with no treatment-related mortality.

Conclusions:

  • The combination of olaratumab, doxorubicin, and ifosfamide (ODI) demonstrates preliminary activity in MSTS.
  • The safety profile of ODI appears comparable to that of doxorubicin and ifosfamide alone in MSTS patients.
Keywords:
DoxorubicinIfosfamideOlaratumabSafetySoft tissue sarcoma

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