Liquid-chromatographic determination of fleroxacin in serum and urine
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W M Awni1, J A Maloney, K L Heim-Duthoy
1College of Pharmacy, University of Minnesota, Minneapolis.
Clinical Chemistry
|November 1, 1988
Abstract:
This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 micrograms/L.