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Highlights of C (sp2 )-H hydrogen isotope exchange reactions
1Radiochemistry Section, Centre for Drug Discovery, RTI International, North Carolina, USA.
Abstract:
The highlights of C (sp2 )-H hydrogen isotope exchange (HIE) methods developed over the past 10 years are summarized in this review. Major developments include improved Ir(I) catalysts with greater functional group and solvent compatibility and the development of novel base metal catalysts for HIE. In addition, a number of novel Ru-based catalysts have been developed with promising activity. In the area of Pt- and Pd-catalysed exchange, in addition to new advances on heterogeneous Pt- and Pd-catalysed HIE by Sajiki and Shevchenko, a number of groups have reported on homogenous catalysts of Pt and Pd that show an interesting activity and selectivity.
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