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Updated: Jan 20, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Three new bioactive diterpenoids from the roots of Croton crassifolius
Guo-Hua Ye1, Jun-Juan Xue1, Wei-Ling Liang1
1School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai, Shandong, 264199, People's Republic of China.
Abstract:
Phytochemical investigation of Croton crassifolius led to the isolation of two new halimane diterpenoids (1 and 2), a new nor-clerodane diterpenoid (3), along with three known analogues (4-6). Their structures including absolute configurations were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and CD analysis. All isolates were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophage cells, and compound 1 exhibited moderate inhibition of NO production with an IC50 value of 25.8 ± 0.9 μM.
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