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Updated: Jan 20, 2026

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Published on: February 8, 2017
Paclitaxel-encapsulated core-shell nanoparticle of cetyl alcohol for active targeted delivery through oral route
Debabrata G Dastidar1, Amlan Das1, Satabdi Datta1
1Department of Biotechnology & Dr BC Guha Centre for Genetic Engineering & Biotechnology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, West Bengal, India.
Abstract:
Aim: Paclitaxel (PTX) has no clinically available oral formulations. Cetyl alcohol is metabolized by alcohol dehydrogenase and aldehyde dehydrogenase that are overexpressed in cancer cells. So, PTX-encapsulated core-shell nanoparticle of cetyl alcohol (PaxSLN) could target the cancer cells through oral route. Materials & methods: PaxSLN was synthesized using microemulsion template. Efficiency of PaxSLN was evaluated by ALDEFLUOR™, multicellular tumor spheroid formation inhibition assays and CT26 colorectal carcinoma animal model. Pharmacokinetics and biodistribution studies were done in Sprague Dawley rats. Results: PTX was encapsulated at the core of approximately 78 nm PaxSLN. PaxSLN targeted aldehyde dehydrogenase overexpressing cells. Its oral bioavailability was approximately 95% and chemotherapeutic efficacy was better than Taxol® and nab-PTX. Conclusion: A novel oral nanoformulation of PTX was developed.
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