Related Experiment Video
Updated: Jan 20, 2026

Development of a Larval Zebrafish Infection Model for Clostridioides difficile
Published on: February 14, 2020
Non-antibiotic therapy for Clostridioides difficile infection: a review
1State Key Laboratory of Microbial Metabolism, and School of Life Science & Biotechnology, Shanghai Jiao Tong University , Shanghai , China.
Abstract:
Clostridioides difficile infection (CDI) is a common infectious disease that is mainly caused by antibiotics. Antibiotic therapy is still the dominant treatment for CDI, although it is accompanied by side effects. Probiotics, fecal microbiota transplantation (FMT), engineered microorganisms, bacteriophages, diet, natural active substances, nanoparticles and compounds are examples of emerging non-antibiotic therapies that have received a great amount of attention. In this review, we collected data about different non-antibiotic therapies for CDI and provided a comprehensive analysis and detailed comparison of these therapies. The mechanism of action, therapeutic efficacy, and the strengths and weaknesses of these non-antibiotic therapies have been investigated to provide a basis for the reasonable alternative of non-antibiotic therapies for CDI. In summary, probiotics and FMT are currently the best choice for non-antibiotic therapy for CDI.
Related Concept Videos
Antibiotic Selection
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Development of Antibiotic Resistance
Gene Therapy
Group Therapy

