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A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
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Cannabidiol (CBD) use in psychiatric disorders: A systematic review
Stefania Bonaccorso1, Angelo Ricciardi2, Caroline Zangani3
1Camden and Islington NHS Mental Health Foundation Trust, London, UK.
Neurotoxicology
|August 15, 2019
Summary
Cannabidiol (CBD) shows limited evidence for psychiatric disorders but may help with substance use, psychosis, and anxiety. More large-scale trials are needed to confirm its safety and effectiveness.
Area of Science:
- Pharmacology
- Psychiatry
- Cannabinoid Research
Background:
- Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are key phytocannabinoids from Cannabis sativa.
- CBD is often associated with medical uses, distinct from THC's psychotomimetic effects.
- Existing research suggests potential applications for CBD in managing chronic pain.
Purpose of the Study:
- To systematically review the efficacy and safety of CBD for psychiatric disorders.
- To assess CBD's effectiveness as a standalone or adjunctive treatment.
- To synthesize evidence from randomized controlled trials (RCTs) across various psychiatric conditions.
Main Methods:
- Systematic review following PRISMA guidelines.
- Inclusion of randomized controlled trials (RCTs) evaluating CBD for psychiatric conditions.
- Screening of 1301 papers, with 27 articles meeting final inclusion criteria.
Main Results:
- Limited evidence currently exists on the safety and efficacy of CBD for psychiatric disorders.
- Preliminary findings suggest potential therapeutic benefits for substance use disorders, chronic psychosis, and anxiety.
- CBD's role in treating a broad spectrum of psychiatric conditions requires further investigation.
Conclusions:
- Current evidence for CBD in psychiatric treatment is limited.
- Potential benefits are noted for specific conditions like anxiety and psychosis.
- Large-scale RCTs are essential to establish efficacy, safety, and abuse potential.
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