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SOX2 in development and cancer biology
Daniel Novak1, Laura Hüser1, Jonathan J Elton1
1Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
Seminars in Cancer Biology
|August 15, 2019
Summary
The transcription factor SOX2 is vital for embryonic development and stemness. Its dysregulation in cancer promotes tumor growth, metastasis, and therapy resistance, highlighting SOX2 as a potential therapeutic target.
Area of Science:
- Developmental Biology
- Cancer Biology
- Stem Cell Research
Background:
- SOX2 is a critical transcription factor for embryonic development and stem cell maintenance.
- Dysregulated SOX2 expression is linked to numerous cancer types.
- SOX2 is implicated in cancer stem cell properties and therapeutic resistance.
Purpose of the Study:
- To summarize current knowledge on SOX2's role in development and stemness.
- To review SOX2's involvement in cancer progression and therapeutic resistance.
- To highlight SOX2 as a potential target for novel cancer therapies.
Main Methods:
- Literature review of studies on SOX2 function.
- Analysis of SOX2's role in embryonic and adult stem cells.
- Examination of SOX2's impact on cancer cell proliferation, migration, invasion, and metastasis.
- Investigation of SOX2's contribution to cancer therapy resistance.
Main Results:
- SOX2 is essential for maintaining pluripotency and stemness.
- SOX2 overexpression drives cancer progression and aggressive phenotypes.
- SOX2 contributes to resistance against various cancer treatments.
- SOX2 is frequently found in cancer stem cells.
Conclusions:
- SOX2 plays a dual role in development and cancer.
- Targeting SOX2 may offer new therapeutic strategies for cancer.
- Further research into SOX2's mechanisms in cancer is warranted.
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