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Updated: Jan 20, 2026

Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice
Published on: August 1, 2025
[Obstructed Defecation: Relevance of Sacral Neuromodulation]
1Chirurgische Klinik I, Universitätsklinikum Würzburg, Deutschland.
Sacral nerve stimulation shows initial promise for chronic constipation but lacks long-term evidence. Further trials are needed to determine its efficacy and identify suitable patient groups for this treatment.
Area of Science:
- Gastroenterology
- Neurology
- Surgical Innovation
Background:
- Sacral nerve stimulation (SNS) initially showed promise for treating chronic constipation and obstructed defecation.
- Early cohort studies suggested positive outcomes for sacral neuromodulation in these conditions.
Purpose of the Study:
- To review the existing literature on sacral nerve stimulation for chronic constipation and obstructed defecation.
- To evaluate the current evidence regarding the long-term efficacy and safety of SNS in these patient populations.
Main Methods:
- Narrative review of published clinical trials and cohort studies.
- Analysis of data concerning efficacy, adverse events, and explantation rates.
Main Results:
- Randomized trials have not demonstrated a significant difference between SNS and control groups.
- Long-term data reveal a loss of efficacy and adverse events in many patients, leading to high explantation rates.
Conclusions:
- Current evidence does not support the routine inclusion of sacral neuromodulation in the treatment algorithm for chronic constipation and obstructed defecation.
- Further research is necessary to identify specific patient cohorts who may benefit from sacral nerve stimulation and establish selection criteria.
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