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Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models

Giuseppe Murdaca1, Alessandro Tonacci2, Simone Negrini3

  • 1Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132 Genoa, Italy. giuseppe.murdaca@unige.it.

International Journal of Molecular Sciences
|August 16, 2019
PubMed
Abstract

Insights

AntagomiRs effectively reduce specific microRNAs (miRNAs) involved in lung diseases. This review confirms their utility across human, animal, and cell models for various pulmonary conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pulmonology

Background:

  • MicroRNAs (miRNAs) are key regulators in lung diseases like cancer, fibrosis, tuberculosis, COPD, and asthma.
  • Recent findings have challenged the oncogenic role of certain miRNAs.
  • AntagomiRs are designed to modulate miRNA turnover.

Purpose of the Study:

  • To systematically review the evidence on microRNAs and their corresponding antagomiRs in lung disorders.
  • To provide a comprehensive overview of antagomiR efficacy in pulmonary diseases.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • PubMed database search from January 2000 to April 2019.
  • Included original English articles on antagomiRs and lung diseases; excluded reviews and meta-analyses.

Main Results:

  • 68 articles met the inclusion criteria.
  • AntagomiRs demonstrated efficiency in downregulating target miRNAs.
  • Efficacy was confirmed in human studies, animal models, and cell lines.

Conclusions:

  • AntagomiRs are effective tools for targeting specific miRNAs in lung disorders.
  • This review offers a comprehensive resource on antagomiRs for major lung diseases.
  • The findings support the therapeutic potential of antagomiRs in pulmonology.
Keywords:
animal modelsantagomiRcellular modelshuman modelslung diseasesmiRNAs

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