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Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
Raghavendhar R Kotha1, Devanand L Luthria2
1USDA-ARS, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA.
Molecules (Basel, Switzerland)
|August 16, 2019
Summary
Turmeric
Area of Science:
- Pharmacology and Analytical Chemistry
- Natural Product Chemistry
Background:
- Turmeric contains bioactive curcuminoids, notably curcumin, with potential therapeutic benefits.
- Poor solubility and bioavailability limit curcumin's clinical application.
- Accurate assessment of curcumin's efficacy is hindered by suboptimal preparation and analysis methods.
Purpose of the Study:
- To review the biological, pharmaceutical, and analytical aspects of curcumin.
- To discuss various curcumin formulation techniques and their clinical outcomes.
- To compare sample preparation and analytical methodologies for curcuminoid extraction and quantification.
Main Methods:
- Review of recent research on curcumin formulations, clinical trials, and in vivo studies.
- Comparison of sample preparation techniques (ultrasonic, pressurized liquid extraction, microwave, reflux).
- Evaluation of analytical methods including spectroscopy (FT-IR, UV, NMR) and chromatography (HPTLC, HPLC, LC-MS/MS).
Main Results:
- Various curcumin formulations have been developed to overcome bioavailability issues.
- Different extraction and analytical methods show varying efficiencies for curcuminoid quantification.
- Optimal methodologies are crucial for accurate bioactivity and efficacy assessment.
Conclusions:
- Improving sample preparation and analytical techniques is essential for reliable curcuminoid analysis.
- Standardized methods will enhance the evaluation of curcumin formulations and their therapeutic potential.
- Further research should focus on optimizing extraction and detection for accurate bioactivity assessment.
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