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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Single mutidrug resistant enterobacteriacae donor-derived infection in four solid organ transplant recipients: a case

Eva Kieslichova1, Marek Protus2, Dana Nemcova3

  • 1Department of Anesthesiology and Intensive Care, Transplantcentre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. evki@ikem.cz.

BMC Surgery
|August 16, 2019
PubMed
Abstract

Insights

Donor bacteraemia can lead to serious post-transplant infections in recipients. Careful screening and targeted antibiotics are crucial to prevent these donor-derived infections, though complete prevention is challenging.

Area of Science:

  • Transplant Infectious Diseases
  • Microbiology
  • Organ Procurement

Background:

  • Donor bacteraemia is not an absolute contraindication for organ procurement.
  • Recipient infection is a significant cause of morbidity and mortality in solid organ transplant (SOT) recipients.
  • Assessing individual risks and applying appropriate antibiotic treatment are vital when using organs from bacteraemic donors.

Observation:

  • A case series reported severe donor-derived infectious complications in four out of five recipients from a single donor.
  • Infections occurred in the early post-transplant period.
  • Donor-transmitted multi-drug resistant strains of Escherichia coli and Klebsiella pneumoniae were identified.

Findings:

  • Multi-drug resistant bacteria transmitted from the donor caused severe infections in SOT recipients.
  • Serologic and molecular testing confirmed donor transmission of Escherichia coli and Klebsiella pneumoniae.
  • Early post-transplant period is critical for monitoring donor-derived infections.

Implications:

  • Rigorous microbiological screening of organ donors is essential to prevent donor-derived infections.
  • Targeted antibiotic therapy based on screening results is crucial for managing bacteraemic donors.
  • Maintaining a high index of suspicion for bacterial infections in both donors and recipients is necessary to improve outcomes.
Keywords:
Donor-derived infectionEarly posttransplant infectionMulti-drug resistant bacteria

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