Related Experiment Videos
c-fos proto-oncogene expression in human NK/LGL cells: expression is not constitutive and is associated with
F Colotta1, N Polentarutti, A Pirelli
1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Abstract:
Unlike mature myeloid and monocytic cells and cell lines committed to terminal myelomonocytic differentiation, highly purified preparations of human natural killer cells/large granular lymphocytes (NK/LGL) did not spontaneously express the c-fos proto-oncogene. Transient expression of c-fos in NK/LGL was associated with functional activation with IL-2, IFN-gamma, LPS and PMA, which increased their cytotoxic activity, lymphokine secretion and in vitro chemotaxis. These results, together with the finding that T-cell receptor genes are in germ-line configuration in the vast majority of peripheral blood NK/LGL, are compatible with the hypothesis that these cells represent a separate hematopoietic lineage.