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Association of apolipoproteins C-I, C-II, C-III and E with coagulation markers and venous thromboembolism risk

Fernanda A Orsi1,2, Willem M Lijfering2,3, Arnoud Van der Laarse4,5

  • 1Department of Clinical Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Clinical Epidemiology
|August 16, 2019
PubMed

Insights

Apolipoproteins C-I, C-II, C-III, and E are linked to coagulation factors. Further research is needed to confirm if these apolipoproteins increase the risk of venous thromboembolism (VTE).

Area of Science:

  • Cardiovascular science
  • Thrombosis research
  • Lipid metabolism

Background:

  • Apolipoproteins C-I, C-II, C-III, and E are implicated in arterial thrombotic diseases.
  • Their potential prothrombotic properties and association with venous thromboembolism (VTE) require investigation.

Purpose of the Study:

  • To determine if apolipoproteins C-I, C-II, C-III, and E possess prothrombotic properties.
  • To investigate the association between these apolipoproteins and the risk of venous thromboembolism (VTE).

Main Methods:

  • A case-control study involving 127 VTE patients and 299 controls from the Netherlands.
  • Quantification of apolipoproteins using liquid chromatography-tandem mass spectrometry (LC/MS/MS).
  • Analysis of apolipoprotein levels as continuous variables (per standard deviation increase).

Main Results:

  • In controls, elevated apolipoprotein levels correlated with increased vitamin K-dependent factors, factor XI, antithrombin, and clot lysis time.
  • Apolipoproteins C-III and E showed associations with higher factor VIII and von Willebrand factor levels.
  • Odds ratios for VTE risk per SD increase in apolipoproteins E, C-III, C-II, and C-I were 1.21, 1.19, 1.24, and 1.06, respectively, remaining significant after adjustments.

Conclusions:

  • Apolipoproteins C-I, C-II, C-III, and E levels are associated with several coagulation factors.
  • The association of these apolipoproteins with an increased risk of VTE requires further confirmation.
Abstract

Keywords:
cholesterolcoagulationlipidsproteomicsthrombosisrisk factors

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