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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

16.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.1K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.5K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

4.4K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
4.4K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

16.1K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.1K
Optimizing Chromatographic Separations01:15

Optimizing Chromatographic Separations

903
Optimizing chromatographic separations is crucial for obtaining clean separations in a minimum amount of time. Optimization is required for several factors, including kinetic effects related to band broadening, plate height, capacity factor, and separation factor.
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
903
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
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Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

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Inflammatory Breast Cancer: a Separate Entity.

Jennifer M Rosenbluth1, Beth A Overmoyer2

  • 1Susan F. Smith Center for Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

Current Oncology Reports
|August 16, 2019
PubMed
Summary

Inflammatory breast cancer (IBC) is an aggressive breast cancer subtype. Research is advancing understanding of its molecular and clinical features to develop targeted therapies.

Keywords:
Clinical trialsDermal lymphatic invasionInflammatory breast cancerLocally advanced breast cancerTumor emboli

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Area of Science:

  • Oncology
  • Cancer Research
  • Medical Science

Background:

  • Inflammatory breast cancer (IBC) is a rare, aggressive breast cancer subtype.
  • IBC significantly contributes to breast cancer mortality.
  • The disease presents with characteristic lymphatic obstruction causing breast swelling and inflammation.

Purpose of the Study:

  • To review the clinical and molecular characteristics of IBC.
  • To identify research gaps and areas for future investigation in IBC.

Main Methods:

  • This is a review article, synthesizing existing research on IBC.
  • Focus on recent studies examining intrinsic tumor cell features and extrinsic immune system interactions.

Main Results:

  • Recent studies highlight signaling pathways involved in IBC growth and stem-like properties.
  • The role of the immune system in IBC pathogenesis is increasingly recognized.
  • Increased awareness and insights into IBC pathogenesis have been achieved.

Conclusions:

  • Despite progress, there is a critical need for novel therapies specifically for IBC.
  • Further research is required to address unanswered questions in IBC treatment and understanding.