Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular interactions in adherens-type contacts.

B Geiger1, T Volk, T Volberg

  • 1Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

Journal of Cell Science. Supplement
|January 1, 1987
PubMed
Summary

This study explores adherens junctions, focusing on vinculin and A-CAM roles in cell contact formation. It investigates molecular interactions and how vinculin mRNA expression is influenced by cell culture conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PKC-PKD-NFκB signaling induces cardiomyocyte t-tubule loss via a conserved macropinocytic mechanism.

Cardiovascular research·2026
Same author

[Peripheral regional anesthesia and analgesia: "the magnificent seven" for training].

Die Anaesthesiologie·2026
Same author

Development and application of a low-noise, high-speed optical detector module for carbon density fluctuation measurements on Wendelstein 7-X.

The Review of scientific instruments·2026
Same author

Measurement of Stark-split beam and carbon charge exchange emissions for simultaneous B-field and temperature/rotation analysis at DIII-D.

The Review of scientific instruments·2024
Same author

Enhancing Thomson scattering polychromator performance with multi-pass spectral filters.

The Review of scientific instruments·2024
Same author

Visible core spectroscopy at Wendelstein 7-X.

The Review of scientific instruments·2024

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Adherens junctions are crucial cell contacts linked to the microfilament system.
  • Understanding their biogenesis and molecular interactions is key to cell adhesion research.

Purpose of the Study:

  • To investigate the role of vinculin and A-CAM in adherens junction formation.
  • To explore molecular interactions within adherens junctions.
  • To examine the regulation of vinculin mRNA expression.

Main Methods:

  • Biochemical analyses
  • Molecular dynamics studies in microinjected living cells
  • Review of evidence on mRNA expression modulation

Main Results:

  • Vinculin, a cytoplasmic plaque component, interacts with junctional domains.
  • A-CAM acts as a 'junctional receptor' involved in cell adhesion.
  • Vinculin mRNA expression is sensitive to culture conditions and substratum adhesiveness.

Conclusions:

  • Vinculin and A-CAM are key players in adherens junction formation and function.
  • Environmental factors significantly influence the expression of key junctional proteins.

Related Experiment Videos