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IRNdb: the database of immunologically relevant non-coding RNAs.

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    The IRNdb database compiles non-coding RNAs (ncRNAs) and their immune targets, aiding research into ncRNA roles in immunity. It offers a user-friendly platform for exploring these crucial gene regulators.

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    Area of Science:

    • Immunology
    • Genetics
    • Bioinformatics

    Background:

    • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are key regulators of biological processes.
    • ncRNA control of gene expression is a critical mechanism within the immune system.
    • The functional roles of many ncRNAs remain largely uncharacterized, hindering research progress.

    Purpose of the Study:

    • To develop a comprehensive database, the IRNdb, for immunologically relevant ncRNAs and their target genes.
    • To facilitate the discovery and characterization of ncRNA functions in immune system regulation.
    • To provide a centralized, searchable resource for researchers studying ncRNAs in immunology.

    Main Methods:

    • Integrated mouse data on predicted and experimentally supported ncRNA-target interactions.
    • Compiled ncRNA and gene annotations, biological pathways, and experimental data.
    • Developed a user-friendly web interface for data access and exploration.

    Main Results:

    • The IRNdb database currently documents 12,930 experimentally supported miRNA-target interactions involving 724 miRNAs and 2,427 immune-related mouse targets.
    • Included are 22,453 lncRNA-immune target and 377 PIWI-interacting RNA-immune target interactions.
    • The database provides a uniform format and a searchable repository of integrated data.

    Conclusions:

    • IRNdb serves as a valuable, comprehensive resource for investigating the roles of ncRNAs in the immune system.
    • The database supports further research into ncRNA-mediated gene regulation in immunological processes.
    • Facilitates the study of ncRNA functions and interactions within the immune context.