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Intermolecular Forces in Solutions02:28

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The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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Related Experiment Video

Updated: Jan 20, 2026

Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture
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Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture

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Reversible Formation of a Light-Responsive Catalyst by Utilizing Intermolecular Cooperative Effects.

Chloe Z-J Ren1,2, Pablo Solís Muñana1,2, Julien Dupont1,2

  • 1Centre for Biomedical and Chemical Sciences, School of Science, Auckland University of Technology, 34 St Paul St, Auckland, 1010, New Zealand.

Angewandte Chemie (International Ed. in English)
|August 16, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a photoresponsive system that links structure formation to catalytic activity. Light controls the assembly of amphiphiles, modulating cooperative catalysis in water for advanced artificial systems.

Keywords:
amphiphilesbiomimetic catalysiscooperative catalysisphoto-switchingsystems chemistry

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Area of Science:

  • Supramolecular Chemistry
  • Catalysis
  • Materials Science

Background:

  • Amphiphiles can self-assemble into vesicular structures.
  • Catalytic activity can arise from intermolecular cooperative effects within these structures.
  • Controlling self-assembly offers a route to controlling catalytic function.

Purpose of the Study:

  • To develop a photoresponsive system where catalytic activity is coupled to self-assembly.
  • To investigate the modulation of catalytic activity by light-induced changes in structure.
  • To demonstrate a new method for designing dynamic, cooperative catalysts in aqueous environments.

Main Methods:

  • Synthesis of amphiphilic pre-catalysts incorporating photoresponsive units.
  • Investigation of self-assembly behavior using techniques like dynamic light scattering and microscopy.
  • Characterization of catalytic activity and its dependence on the assembled state.
  • Photo-switching experiments to control assembly and disassembly.

Main Results:

  • Demonstrated light-induced reversible switching between assembled vesicular structures and disassembled states.
  • Established a direct correlation between the assembled state and observed catalytic activity.
  • Showcased that cooperative effects, crucial for catalysis, are dependent on vesicular formation.
  • Confirmed the system's functionality in aqueous media.

Conclusions:

  • Photoresponsive amphiphiles can reversibly control self-assembly and catalytic activity.
  • Coupling structure formation to catalysis via light offers a novel approach for dynamic systems.
  • This work provides a new strategy for designing responsive, cooperative catalysts in water.