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Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
Published on: October 16, 2016
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Plasma Long Non-Coding RNA Expression Profiles in Patients with Rheumatoid Arthritis
Clinical Laboratory
|August 16, 2019
Summary
This study reveals distinct long non-coding RNA (lncRNA) expression profiles in rheumatoid arthritis (RA) plasma, identifying potential diagnostic biomarkers and therapeutic targets for RA. The findings highlight lncRNAs
Area of Science:
- Molecular Biology
- Genomics
- Biochemistry
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in biological processes.
- Understanding lncRNA expression in rheumatoid arthritis (RA) is important for disease insights.
Purpose of the Study:
- To characterize plasma lncRNA expression profiles in rheumatoid arthritis (RA) patients.
- To identify differentially expressed lncRNAs and messenger RNAs (mRNAs) in RA plasma.
Main Methods:
- Gene expression microarray analysis of plasma from RA patients and healthy controls.
- Bioinformatics analysis including Gene Ontology (GO) and pathway enrichment.
- Construction of a lncRNA-mRNA co-expression network.
Main Results:
- Identified 289 differentially expressed (DE) lncRNAs and 468 DE mRNAs in RA plasma.
- DE mRNAs are potentially involved in RA pathogenesis via platelet pathways.
- Constructed a co-expression network of 116 lncRNAs and 113 mRNAs.
Conclusions:
- First characterization of plasma lncRNA expression profiles in RA patients.
- Results offer new insights into RA pathogenesis.
- Identified potential novel diagnostic biomarkers and therapeutic targets for RA.
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