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T Helper 9 Cells: A New Player in Immune-Related Diseases
Jing Chen1,2, Lian Guan1,2, Lin Tang1,2
1Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi, Guizhou, China.
Abstract:
The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4+T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cytokine transforming growth factor β, IL-4, and various transcription factors. Th9 cells, as a new player, played an important role in various immune-related diseases, including tumors, inflammatory diseases, parasite infection, and other diseases. In this article, we summarize the related research progress and discuss the possible prospect.
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