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Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
Published on: February 8, 2017
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Strategies to prevent brain metastasis
Riccardo Soffietti1, Alessia Pellerino, Roberta Rudà
1Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
Current Opinion in Oncology
|August 16, 2019
Summary
Preventing brain metastases involves cranial irradiation for small cell lung cancer, improving survival. New molecular strategies are emerging for other cancers to target micrometastases and reduce brain relapse.
Area of Science:
- Oncology
- Neuro-oncology
- Cancer Prevention
Background:
- Brain metastases are a significant challenge in solid tumor management.
- Current prevention strategies aim to reduce central nervous system relapse.
- Advances in molecular biology offer new avenues for targeted therapies.
Purpose of the Study:
- To review current and emerging strategies for preventing brain metastases from solid tumors.
- To discuss the role of prophylactic cranial irradiation (PCI) in lung cancer.
- To explore novel personalized molecular approaches for micrometastasis targeting.
Main Methods:
- Review of pivotal studies and recent clinical trials.
- Analysis of prophylactic cranial irradiation (PCI) efficacy and toxicity.
- Evaluation of pharmacologic prevention strategies and targeted agents.
Main Results:
- PCI improves overall survival in small cell lung cancer (SCLC) but carries risks of cognitive deficits.
- PCI reduces brain metastases incidence and prolongs disease-free interval in non-small cell lung cancer (NSCLC) without improving overall survival.
- Pharmacologic prevention shows promise, particularly with targeted agents for specific molecular subgroups.
Conclusions:
- Future prevention requires identifying high-risk patient subgroups.
- Developing novel whole brain radiotherapy (WBRT) strategies to preserve cognition is crucial.
- Targeting micrometastases with molecular agents represents a key future direction.
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