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Updated: Jan 20, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Retinal Defects Three Months After Intravitreal Dexamethasone Implant
Intravitreal dexamethasone implants can cause retinal defects, a rare complication not due to impact injury. This finding highlights a potential destructive effect of the implant on adjacent retinal tissue.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Ocular Surgery
Background:
- Intravitreal dexamethasone implants are standard treatments for macular edema and noninfectious uveitis.
- Common side effects include glaucoma and cataract formation.
- Impact injury from the implant is a rare, but known, complication.
Observation:
- A patient developed peripheral retinal defects three months after receiving a dexamethasone implant.
- The affected eye was vitrectomized, and the implant was abutting the retina without evidence of traction.
- No flap, operculum, or other signs of impact injury were present.
Findings:
- The dexamethasone implant itself appeared to cause destruction of the juxtaposed retinal tissue.
- This represents a previously unreported complication of intravitreal dexamethasone implants.
- The retinal defects were not caused by direct impact injury.
Implications:
- This finding suggests a direct toxic or destructive effect of the implant on retinal tissue.
- Ophthalmologists should be aware of this potential complication when managing patients with intravitreal implants.
- Further investigation is needed to understand the mechanism of retinal tissue destruction.
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