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Influence of the Matrix Metalloproteinase 9 Geners3918242 Polymorphism on Development of Ischemic Stroke: A

Guangliang Wu1, Haiyan Cai2, Guoming Li1

  • 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

World Neurosurgery
|August 16, 2019
PubMed
Abstract

Insights

The matrix metalloproteinase 9 (MMP-9) gene rs3918242 polymorphism is linked to ischemic stroke (IS) risk. This genetic variant may serve as a predictor for IS susceptibility across diverse populations.

Area of Science:

  • Genetics and Molecular Biology
  • Neurology
  • Epidemiology

Background:

  • The association between the matrix metalloproteinase 9 (MMP-9) gene -1562C/T (rs3918242) polymorphism and ischemic stroke (IS) susceptibility remains unclear.
  • Previous studies yielded ambiguous and inconsistent results regarding this genetic association.

Purpose of the Study:

  • To comprehensively assess the potential relationship between the MMP-9 rs3918242 polymorphism and the risk of developing ischemic stroke.
  • To clarify the inconsistent findings from prior investigations on this genetic marker and IS.

Main Methods:

  • A meta-analysis of case-control studies was conducted.
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to quantify associations.
  • Meta-regression, heterogeneity, cumulative, sensitivity, and publication bias analyses were performed.

Main Results:

  • Nineteen studies involving the rs3918242 polymorphism and IS risk were analyzed.
  • Significant associations were found in the overall population, Asians, whites, males, and females.
  • The polymorphism correlated with large artery atherosclerosis subtypes, individuals aged ≥65 years, and both diabetic and non-diabetic subgroups. Smokers showed increased IS risk.

Conclusions:

  • The MMP-9 rs3918242 polymorphism may act as a predictive marker for ischemic stroke susceptibility.
  • Further large-scale studies are warranted to validate these findings and confirm the predictive value.
Keywords:
1562C/TIschemic strokeMMP-9Polymorphismrs3918242

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