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Systemic lupus erythematosus and hypertension.
Pamela Munguia-Realpozo1, Claudia Mendoza-Pinto2, Cristina Sierra Benito3
1Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE, Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico; Immunology and Rheumatology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Autoimmunity Reviews
|August 16, 2019
Summary
Hypertension is common in systemic lupus erythematosus (SLE) and linked to cardiovascular disease, but its causes and management in SLE patients are poorly understood. This review explores hypertension mechanisms, screening, and treatment in SLE.
Area of Science:
- Nephrology
- Rheumatology
- Cardiology
Background:
- Systemic lupus erythematosus (SLE) significantly increases cardiovascular disease (CVD) risk, partly due to hypertension.
- Hypertension is more prevalent in SLE patients than in the general population.
- The mechanisms driving hypertension in SLE remain unclear.
Purpose of the Study:
- To review the potential mechanisms of hypertension in SLE.
- To evaluate current literature on hypertension screening and management in SLE patients.
- To highlight the need for specific hypertension guidelines in SLE.
Main Methods:
- Literature review of studies on hypertension in SLE.
- Discussion of pathophysiological mechanisms.
- Analysis of 24-h ambulatory blood pressure monitoring data.
Main Results:
- Hypertension is a frequent complication in SLE patients.
- Hypertension in SLE is associated with increased organ damage, stroke, and cognitive issues.
- Current clinical guidelines lack specific recommendations for managing hypertension in SLE.
Conclusions:
- Understanding hypertension mechanisms in SLE is crucial.
- 24-h ambulatory blood pressure monitoring is valuable for assessing BP in SLE.
- Tailored hypertension management strategies are needed for SLE patients.
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