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Phase I study of recombinant gamma-interferon (rIFN-gamma)
B M Boman1, M M Gagen, E Bonnem
1Department of Medical Oncology, Univerity of Texas, M.D. Anderson Hospital and Tumor Institute, Houston.
Journal of Biological Response Modifiers
|October 1, 1988
Abstract:
A Phase I study of recombinant gamma-interferon was conducted in 35 patients with advanced malignancy. The schedule was twice weekly administered intravenously. Patients were assigned to six dose levels. The major toxicities were flu-like symptoms and were unrelated to dose. Other adverse reactions, such as myelosuppression, were dose dependent. The addition of a nonsteroidal anti-inflammatory agent did not ameliorate the symptoms at the highest dose level. Antitumor effects occurred in patients with gastric, duodenal, and breast carcinoma.