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Updated: Jan 20, 2026
Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
Published on: June 8, 2016
Stereoselective Total Synthesis of Aspergillide A: A Visible Light-Mediated Photoredox Access to the Trisubstituted
Jeferson B Mateus-Ruiz1, Alejandro Cordero-Vargas1
1Instituto de Química , Universidad Nacional Autónoma de México , Circuito Exterior s/n, Ciudad Universitaria , Coyoacán, C.P. 04510 México D.F. , Mexico.
Abstract:
A stereoselective total synthesis of natural product aspergillide A is reported. The adopted strategy relies on the direct access to the key tetrahydropyran core through a visible light-mediated photoredox reaction from an allylic alcohol and iodoacetic acid. In a single manipulation, a γ-iodo-δ-valerolactone is obtained through an atom transfer radical addition followed by in situ acid-catalyzed lactonization. The obtained lactone possesses three functionalized sites, which were seized to link the required substituents in the final product and thus completing the total synthesis of aspergillide A.
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