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The significance of gene mutations across eight major cancer types

Prosenjit Paul1, Arup Kumar Malakar1, Supriyo Chakraborty1

  • 1Department of Biotechnology, Assam University, Silchar, 788011, Assam, India.

Mutation Research. Reviews in Mutation Research
|August 17, 2019
PubMed

Insights

Mutations, spontaneous or induced, can alter cellular functions and gene states. This review summarizes mutation effects on cancer development and consequences for researchers.

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • Mutations arise spontaneously or due to external factors like chemicals and viruses.
  • While not all mutations are significant, those in critical genes can cause developmental disorders.
  • Mutations are fundamental to the transformation of proto-oncogenes into oncogenes, driving cancer initiation.

Purpose of the Study:

  • To review and summarize current knowledge on the effects of mutations in various cancer types.
  • To provide a concise overview of mutation consequences for researchers in cancer biology.
  • To serve as a reference for understanding the role of genetic alterations in cancer development.

Main Methods:

  • Literature review of extensive research on cancer biology.
  • Synthesis of information on genes and pathways involved in cancer development.
  • Summarization of current knowledge on mutational effects and their consequences.

Main Results:

  • Accumulation of mutations throughout life is a key factor in cancer development.
  • Specific mutations can alter proto-oncogenes into oncogenic forms.
  • Understanding mutational effects is crucial for cancer research and treatment strategies.

Conclusions:

  • Mutations play a pivotal role in the initiation and progression of various cancers.
  • This review consolidates knowledge on mutation impacts, aiding future cancer research.
  • Further research into mutational effects can guide the development of targeted cancer therapies.
Keywords:
CancerGenetic variationHeredityMutation

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