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Activity of ceftaroline against pathogens associated with community-acquired pneumonia collected as part of the AWARE

In-Gyu Bae1, Gregory G Stone2

  • 1Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.

Diagnostic Microbiology and Infectious Disease
|August 17, 2019
PubMed

Insights

Ceftaroline shows high susceptibility against common respiratory pathogens like Streptococcus pneumoniae and MRSA, but is not effective against ESBL-producing bacteria. This global data highlights ceftaroline

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance is a growing global health threat.
  • Ceftaroline is a cephalosporin antibiotic with activity against Gram-positive and some Gram-negative bacteria.
  • Understanding regional susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To evaluate the global activity of ceftaroline against key respiratory pathogens.
  • To assess ceftaroline susceptibility in Streptococcus pneumoniae, Staphylococcus aureus (MRSA), Haemophilus influenzae, Klebsiella pneumoniae, and Escherichia coli.
  • To analyze data from the Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) program.

Main Methods:

  • Analysis of isolates collected from lower respiratory tract infections in 2015-2016.
  • Minimum Inhibitory Concentrations (MICs) determined by CLSI broth microdilution.
  • Susceptibility interpreted using EUCAST breakpoints.

Main Results:

  • High ceftaroline susceptibility observed for penicillin-resistant S. pneumoniae (77.4%-100%) and MRSA (72.3%-100%) across regions.
  • Ceftaroline demonstrated good activity against beta-lactamase-positive H. influenzae (69.2%-100%) and non-ESBL-producing K. pneumoniae (91.4%-100%) and E. coli (85.7%-92.1%).
  • Ceftaroline was not active against ESBL-producing Enterobacteriaceae.

Conclusions:

  • Ceftaroline exhibits significant in vitro activity against key Gram-positive and Gram-negative respiratory pathogens globally.
  • Susceptibility to ceftaroline remains high for common resistant pathogens like penicillin-resistant S. pneumoniae and MRSA.
  • Ceftaroline is not a reliable option for infections caused by ESBL-producing bacteria.
Keywords:
AWARECeftarolineCommunity-acquired pneumoniaLower respiratory tract infectionSurveillance

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