Dynamic cell-cell adhesion mediated by pericellular matrix interaction - a hypothesis.
1Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada r.winklbauer@utoronto.ca.
Journal of Cell Science
|August 17, 2019
Summary
Cell adhesion strength is not solely due to cadherins. Pericellular matrix interactions, like hydrogels, explain strong cell adhesion and tissue cohesion, supporting differential adhesion models.
Area of Science:
- Biophysics
- Cell Biology
- Materials Science
Background:
- Cell-cell adhesion strength varies greatly across cell types.
- Cadherin-based mechanisms may not fully explain high adhesion in certain tissues.
Purpose of the Study:
- To explore the hypothesis that pericellular matrix interactions drive strong cell adhesion.
- To link tissue surface tension to pericellular matrix properties.
Main Methods:
- Investigated cell adhesion mechanisms beyond cadherins.
- Analyzed quantitative data from biofilm matrices.
- Examined pericellular matrix interactions and tissue mechanics.
Main Results:
- Cell adhesion strength is influenced by pericellular matrix interactions.
- This mechanism resembles self-adhesion in dynamically cross-linked hydrogels.
- Tissue surface tension correlates with pericellular matrix stiffness.
Conclusions:
- Pericellular matrix interactions provide a mechanism for strong cell adhesion.
- This model explains tissue cohesion and cell sorting phenomena.
- Rehabilitates Steinberg's differential adhesion hypothesis.
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