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Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based

Xiaotong Dai1, Ying Yang2, Guan-Liang Cheng2

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|August 17, 2019
PubMed

Insights

Arterial stiffness, measured by brachial-ankle pulse wave velocity, significantly increases when high blood glucose and high blood pressure coexist. This highlights the combined risk of diabetes and hypertension for cardiovascular health.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Vascular Biology

Background:

  • Increased arterial stiffness, a predictor of cardiovascular disease, is linked to brachial-ankle pulse wave velocity (baPWV).
  • The interplay between blood glucose, blood pressure, and the progression of arterial stiffness remains incompletely understood.
  • Understanding these relationships is crucial for managing cardiovascular risk.

Purpose of the Study:

  • To investigate the association between blood glucose levels and baPWV.
  • To examine the relationship between blood pressure levels and baPWV.
  • To explore the combined effects of diabetes and hypertension on arterial stiffness.

Main Methods:

  • Utilized baseline data from a Chinese community-based atherosclerosis cohort of 7402 individuals.
  • Employed generalized linear regression models to analyze relationships.
  • Stratified analyses were performed based on hypertensive and diabetic states.

Main Results:

  • A significant interaction was observed between hypertensive and diabetic states concerning baPWV (P < 0.001).
  • Individuals with both diabetes and hypertension exhibited the highest risk for increased baPWV (B=403.24; 95% CI: 372.43-434.05; P<0.001).
  • Higher blood pressure was prevalent among participants with increased arterial stiffness.

Conclusions:

  • Increased arterial stiffness is common in individuals with elevated blood pressure.
  • The co-occurrence of high blood glucose and high blood pressure markedly exacerbates arterial stiffness.
  • This finding underscores the critical importance of managing both conditions to mitigate cardiovascular risk.

Keywords:
communitiesdiabeteshypertension

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