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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Biomarkers in Post-kala-azar Dermal Leishmaniasis
1Rotterdam Centre for Tropical Medicine, Rotterdam, Netherlands.
Frontiers in Cellular and Infection Microbiology
|August 17, 2019
Summary
Post-kala-azar dermal leishmaniasis (PKDL) is a skin condition following visceral leishmaniasis. New biomarkers are crucial for accurate diagnosis and effective treatment monitoring of PKDL.
Area of Science:
- Dermatology
- Infectious Diseases
- Parasitology
Background:
- Post-kala-azar dermal leishmaniasis (PKDL) is a common sequela of visceral leishmaniasis (VL), affecting 10-60% of patients.
- PKDL presents as an asymptomatic skin rash, often on the face, with macules, papules, or nodules.
- Clinical diagnosis is challenging in endemic areas, necessitating reliable diagnostic tools.
Purpose of the Study:
- To review current biomarkers for Post-kala-azar dermal leishmaniasis (PKDL).
- To discuss promising new developments in PKDL biomarker research.
- To address the need for improved diagnostic and monitoring tools for PKDL.
Main Methods:
- Review of existing literature on PKDL biomarkers.
- Analysis of parasitological, serological, immunological, and pathological markers.
- Evaluation of clinical assessment methods, including grading and photography.
Main Results:
- Current diagnostic methods for PKDL have limitations in field settings.
- Parasitological confirmation is preferred for guiding drug treatment decisions.
- Assessing treatment response in PKDL is difficult due to slow healing, risking prolonged therapy.
Conclusions:
- There is a critical need for validated biomarkers in Post-kala-azar dermal leishmaniasis (PKDL).
- Biomarkers are essential for accurate diagnosis, differentiating PKDL from other skin conditions, and monitoring treatment efficacy.
- Future research should focus on developing and validating novel biomarkers for improved PKDL management.
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