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Biomarkers for Predicting Efficacies of Anti-PD1 Antibodies

Yumi Kambayashi1, Taku Fujimura1, Takanori Hidaka1

  • 1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Frontiers in Medicine
|August 17, 2019
PubMed

Insights

Predicting advanced melanoma treatment response is crucial. This review explores biomarkers, including blood tests and PD-L1 expression, to assess anti-programmed cell death 1 (PD1) antibody efficacy, aiding treatment decisions.

Area of Science:

  • Oncology
  • Immunotherapy
  • Biomarker Discovery

Background:

  • Advanced melanoma treatment is rapidly evolving with anti-programmed cell death 1 (PD1) antibodies.
  • Current therapies show limited efficacy, particularly in Asian populations.
  • Predictive biomarkers are essential to guide treatment and mitigate adverse events.

Purpose of the Study:

  • To review recent developments in biomarkers for assessing anti-PD1 antibody efficacy in advanced melanoma.
  • To identify potential biomarkers detectable through routine blood tests and tumor analysis.

Main Methods:

  • Literature review of studies on biomarkers for anti-PD1 therapy response.
  • Analysis of various biomarkers including neutrophil-to-lymphocyte ratio, eosinophil ratio, lactate dehydrogenase, PD-L1 expression, microsatellite instability, mismatch repair deficiency, soluble CD163, and chemokines (CXCL5, CXCL10).

Main Results:

  • Several biomarkers show promise in predicting or evaluating anti-PD1 antibody efficacy.
  • Routine blood tests and PD-L1 expression are key areas of investigation.
  • Tumor-based assays like MSI and dMMR also play a role.

Conclusions:

  • Developing reliable biomarkers is critical for optimizing advanced melanoma treatment with anti-PD1 antibodies.
  • Further research is needed to validate these biomarkers for clinical application.
  • Biomarker-guided therapy can improve patient outcomes and reduce unnecessary toxicity.
Keywords:
LDHMSHTAM-related factorsTMBanti-PD1 antibodiesroutine blood test

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