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Updated: Jan 20, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Diterpenoids of terrestrial origin.

James R Hanson¹, Tyler Nichols, Yousef Mukhrish

¹Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QJ, UK. m.c.bagley@sussex.ac.uk.

Natural Product Reports

|August 17, 2019

Summary

This review details the isolation and chemistry of terrestrial diterpenoids, covering labdanes, clerodanes, and other related compounds from 2017. It highlights advancements in understanding these natural products and their cyclization pathways.

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Area of Science:

Natural Product Chemistry
Organic Chemistry

Background:

Diterpenoids are a diverse class of natural products with significant biological activities.
Terrestrial sources are rich reservoirs of unique diterpenoid structures.

Purpose of the Study:

To review the isolation and chemical characterization of terrestrial diterpenoids.
To provide a comprehensive overview of labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes, and their cyclization products.

Main Methods:

Literature review of scientific publications from January to December 2017.
Compilation and analysis of reported isolation and structural elucidation data for diterpenoids.

Main Results:

Summarizes the isolation and chemistry of various terrestrial diterpenoids.
Includes detailed information on labdanes, clerodanes, abietanes, pimaranes, kauranes, and cembranes.
Discusses the cyclization products of these diterpenoids.

Conclusions:

Highlights the continued exploration and discovery of novel terrestrial diterpenoids.
Underscores the importance of these compounds in natural product research.