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Updated: Jan 20, 2026

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays
Published on: March 14, 2011
Short Communication: Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection
Benjamin Bonnet1, Laurent Blum2, Charlotte Charpentier3
1Département d'Immunologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
Abstract:
We report the case of a patient with a very profound CD4 T cell lymphopenia <20 cells/mm3 in the context of a primary HIV-1 infection, associated with both delayed HIV-specific antibody and CD8 T cell responses. A long-term immune reconstitution was observed after immediate initiation of antiretroviral therapy.
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