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Updated: Jan 20, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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Therapeutic use of regulatory T cells for graft-versus-host disease

Shlomo Elias1, Alexander Y Rudensky1

  • 1Howard Hughes Medical Institute and Immunology Program and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

British Journal of Haematology
|August 17, 2019
PubMed

Regulatory T cells (Treg cells) represent a CD4+ T-cell lineage that plays a critical role in restraining immune responses to self and foreign antigens and associated inflammation. Due to the suppressive function of Treg cells, inhibition or ablation of these cells can be used to boost the immunity against malignant cells. On the other hand, augmenting the activity of Treg cells can be employed for the treatment of inflammatory or autoimmune diseases and allogeneic conflicts associated with transplantation. Graft-versus-host disease (GvHD) is a leading cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT). In this review, we describe basic biological properties of Treg cells and their role in GvHD. We focus on the application of adoptive transfer of Treg cells and the therapeutic modulation of their activity for the prevention and treatment of GvHD in pre-clinical models and in clinical settings. We also discuss the main obstacles to applying Treg cell-based therapies for GvHD in clinical practice.

Keywords:
IL-2graft-versus-host diseaseimmunotherapyrapamycintreg cells

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