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Relevance function of microRNA-708 in the pathogenesis of cancer

Si-Nan Sun1, Shuang Hu2, Yu-Ping Shang3

  • 1The First Affiliation Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.

Cellular Signalling
|August 17, 2019
PubMed

Insights

MicroRNA-708 (miR-708) plays a role in various cancers, with altered expression levels observed in lung, bladder, and colorectal cancers. This review explores miR-708

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression, impacting over 70% of human genes.
  • MicroRNA-708 (miR-708), encoded within the ODZ4 gene, is implicated in various cancers.
  • Aberrant miR-708 expression is observed in multiple cancer types, with distinct patterns in lung, bladder, colorectal, hepatocellular, prostate, and gastric cancers.

Purpose of the Study:

  • To review the current understanding of miR-708's association with various cancers.
  • To focus on recent studies concerning miR-708 regulation and its role in cancer.
  • To discuss the potential of miR-708 as an epigenetic biomarker and therapeutic target.

Main Methods:

  • Literature review of recent studies on miR-708 and cancer.
  • Analysis of miR-708 expression patterns in different cancer types.
  • Examination of miR-708 regulatory mechanisms and clinical applications.

Main Results:

  • miR-708 expression is elevated in lung, bladder, and colorectal cancers.
  • miR-708 expression is decreased in hepatocellular, prostate, and gastric cancers.
  • The review highlights miR-708's involvement in cancer development and progression.

Conclusions:

  • miR-708 exhibits differential expression across various cancers, suggesting its potential as a cancer biomarker.
  • Understanding miR-708 regulation and mechanisms is crucial for its therapeutic application.
  • miR-708 represents a promising target for epigenetic therapy and cancer treatment.
Keywords:
CancerClinical applicationMicroRNAMicroRNA-708

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