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STING modulators: Predictive significance in drug discovery
Xiangling Cui1, Rongyu Zhang2, Shan Cen3
1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, PR China; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
European Journal of Medicinal Chemistry
|August 17, 2019
Summary
The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway is crucial for immune responses. STING modulators offer potential treatments for infections, cancer, and autoimmune diseases.
Area of Science:
- Immunology
- Molecular Biology
- Pharmacology
Background:
- The cGAS-STING pathway is essential for innate immunity against DNA.
- STING pathway dysregulation is implicated in various diseases.
- Understanding STING's structure and function is key for therapeutic development.
Purpose of the Study:
- To review recent advancements in STING pathway research.
- To discuss the structure, function, and disease relevance of STING.
- To highlight the progress and rationale behind developing STING modulators.
Main Methods:
- Literature review of studies on the STING pathway.
- Analysis of structural and functional data of STING.
- Examination of disease associations and therapeutic strategies.
Main Results:
- STING pathway modulation is a viable therapeutic strategy.
- Small molecule modulators of STING are under active development.
- STING agonists and antagonists show promise for diverse diseases.
Conclusions:
- STING represents a significant drug target for immune-related conditions.
- Further development of STING modulators could lead to novel treatments.
- Targeting the STING pathway holds potential for infectious diseases, cancer, and autoimmune disorders.
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