Related Experiment Video
Updated: Jan 20, 2026

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay
Published on: May 25, 2015
Psychosocial working conditions across working life may predict late-life physical function: a follow-up cohort study
Charlotta Nilsen1, Ross Andel2,3,4, Alexander Darin-Mattsson5
1Aging Research Center (ARC), Karolinska Institutet/Stockholm University, Tomtebodavägen 18A, SE-171 65, Stockholm, Sweden. charlotta.nilsen@ki.se.
Background:
Increasing life expectancy has made understanding the mechanisms underlying late-life health and function more important. We set out to investigate whether trajectories of change in psychosocial working conditions are associated with late-life physical function.
Methods:
Two Swedish surveys, linked at the individual level, were used (n = 803). A psychosocial job exposure matrix was used to measure psychosocial working conditions during people's first occupation, as well as their occupation every five years thereafter until baseline in 1991. Physical function was measured in 2014. Random effects growth curve models were used to calculate intraindividual trajectories of working conditions. Predictors of physical function were assessed with ordered logistic regression.
Results:
A more active job at baseline was associated with increased odds of late-life physical function (OR 1.15, CI 1.01-1.32). Higher baseline job strain was associated with decreased odds of late-life physical function (OR 0.75, CI 0.59-0.96). A high initial level followed by an upward trajectory of job strain throughout working life was associated with decreased odds of late-life physical function (OR 0.32, CI 0.17-0.58).
Conclusions:
Promoting a healthier workplace by reducing chronic stress and inducing intellectual stimulation, control, and personal growth may contribute to better late-life physical function.
More Related Videos
Related Concept Videos
Functions of Life
Metabolism
The basic function of an organism is to consume energy and molecules in foods, convert some of it into fuel for movement, sustain body functions, and build and maintain body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process whereby...
Half-life of a Reaction
Classical Conditioning in Daily Life
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
Characteristics of Life
The Angiosperm Life Cycle
The Tree of Life - Bacteria, Archaea, Eukaryotes

