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Related Experiment Videos

Parasite-directed endocytosis.

Z A McGee1, G L Gorby, P B Wyrick

  • 1Center for Infectious Diseases, University of Utah School of Medicine, Salt Lake City 84132.

Reviews of Infectious Diseases
|July 1, 1988
PubMed
Summary
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Gonococci invade human cells through parasite-directed endocytosis, a process where microbes, not host cells, initiate entry into epithelial tissues. This mechanism is crucial for pathogen invasion across various host barriers.

Area of Science:

  • Microbiology
  • Cell Biology
  • Pathogenesis

Background:

  • Gonococci (Neisseria gonorrhoeae) are pathogenic bacteria that infect human mucosal surfaces.
  • Understanding the mechanisms of bacterial invasion is critical for developing effective treatments.

Purpose of the Study:

  • To elucidate the mechanism by which gonococci invade human fallopian tube mucosa.
  • To characterize the process as parasite-directed endocytosis.

Main Methods:

  • Organ culture of human fallopian tube mucosa.
  • Microscopic observation of gonococci-epithelial cell interactions.

Main Results:

  • Gonococci attach to and are endocytosed by specialized low columnar epithelial cells.

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  • The bacteria are transported to the base of epithelial cells and exocytosed into subepithelial tissues.
  • This transepithelial transport is dependent on microbial factors.

    • Conclusions:

    • The invasion process is defined as parasite-directed endocytosis, initiated by the pathogen.
    • This mechanism is distinct from host-directed endocytosis (e.g., by macrophages).
    • Parasite-directed endocytosis is a common invasion strategy for various human pathogens.