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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.2K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Related Experiment Video

Updated: Jan 20, 2026

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

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Epilepsy surgery.

Fergus Rugg-Gunn1, Anna Miserocchi2, Andrew McEvoy2

  • 1Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK f.rugg-gunn@ucl.ac.uk.

Practical Neurology
|August 18, 2019
PubMed
Summary
This summary is machine-generated.

Epilepsy surgery can achieve seizure remission for individuals with drug-resistant focal epilepsy. This treatment, including resective and palliative procedures, is underutilized but recommended for refractory cases.

Keywords:
epilepsyepilepsy surgery

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Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Epilepsy surgery offers seizure remission for 30-40% of patients with focal epilepsy unresponsive to anti-epileptic drugs.
  • Surgical options include resective procedures and palliative techniques like corpus callosotomy or device implantation.

Purpose of the Study:

  • To evaluate the efficacy and indications for epilepsy surgery.
  • To outline pre-surgical evaluation methods and factors influencing outcomes.

Main Methods:

  • Pre-surgical evaluation involves advanced imaging (MRI, nuclear medicine), prolonged video-electroencephalogram (EEG) monitoring, and neuropsychological/psychiatric assessments.
  • Intracranial EEG may be required for complex cases.

Main Results:

  • Seizure freedom rates reach 60-70% in patients with MRI-concordant structural lesions.
  • Outcomes are less favorable for extra-temporal foci, focal-to-bilateral tonic-clonic seizures, normal imaging, or comorbidities.

Conclusions:

  • Epilepsy surgery is underused and should be considered for all patients with refractory focal epilepsy.
  • Optimal pre-surgical evaluation is crucial for maximizing outcomes and minimizing deficits.