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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

335
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
335
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

957
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
957
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

479
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
479
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

382
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
382

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Related Experiment Video

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Quantification of Atherosclerosis in Mice
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Atherosclerosis.

Peter Libby1, Julie E Buring2, Lina Badimon3

  • 1Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. plibby@bwh.harvard.edu.

Nature Reviews. Disease Primers
|August 18, 2019
PubMed
Summary

Atherosclerosis, a major cause of heart attacks and strokes, involves artery wall lesions. Research advances diagnostics and therapies, improving patient outcomes and quality of life.

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Area of Science:

  • Cardiovascular Biology and Medicine
  • Immunology of Atherosclerosis

Background:

  • Atherosclerosis, characterized by fibrofatty lesions in artery walls, is a leading global cause of morbidity and mortality.
  • Key risk factors include low-density lipoprotein (LDL) cholesterol, hypertension, smoking, diabetes, inflammation, and clonal hematopoiesis.
  • Understanding the cell and molecular biology of atherogenesis is crucial for linking risk factors to disease manifestations.

Purpose of the Study:

  • To provide an overview of the current understanding of atherosclerosis, its risk factors, and management.
  • To highlight advancements in diagnostic techniques and therapeutic strategies for cardiovascular disease.
  • To emphasize the ongoing challenges and future directions in combating atherosclerosis.

Main Methods:

  • Review of existing literature on atherosclerosis, atherogenesis, and cardiovascular disease.
  • Discussion of various diagnostic modalities, including invasive and noninvasive techniques.
  • Analysis of current therapeutic approaches and challenges in treatment adherence and access.

Main Results:

  • Atherosclerotic lesion development is linked to multiple risk factors, including lipoproteins, hypertension, smoking, diabetes, inflammation, and clonal hematopoiesis.
  • A wide range of diagnostic tools are available for assessing cardiovascular disease risk.
  • Effective therapies exist to modify risk factors and improve clinical outcomes, though access and adherence remain challenges.

Conclusions:

  • Continued research and knowledge acceleration are vital for further progress in preventing and treating atherosclerosis.
  • Clinical application of research findings has improved preventive strategies, patient outcomes, and quality of life.
  • Addressing challenges in equitable access to care and treatment adherence is essential for maximizing the benefits of current and future therapies.