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On the prevention of rhesus immunisation in the RSA
1Genetic Services, Department of National Health and Population Development, Pretoria.
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|November 19, 1988
Summary
The Rh immunoglobulin (anti-Rh antiserum) utilization rate in South Africa was low, especially for Black populations, indicating a need for improved primary healthcare in preventing Rh disease.
Area of Science:
- Medical Science
- Public Health
- Immunology
Background:
- Rh incompatibility poses a risk of hemolytic disease in newborns.
- Prophylactic anti-Rh antiserum is crucial for preventing Rh sensitization in pregnant women.
Purpose of the Study:
- To investigate the utilization rate of anti-Rh antiserum in South African population groups from 1983-1985.
- To assess the effectiveness of primary healthcare in managing Rh incompatibility.
Main Methods:
- Calculated the number of pregnancies at risk based on Rh-negative frequencies.
- Related distributed anti-Rh antiserum doses to the number of women requiring treatment.
- Determined crude utilization rates for different population groups.
Main Results:
- Overall utilization rate was 41-44% across all South African population groups.
- Utilization rates varied significantly: Blacks (14-20%), Whites (89-94%), Indians (59-64%), Coloureds (45-51%).
Conclusions:
- Crude utilization rates suggest suboptimal use of anti-Rh antiserum, particularly in Black populations.
- Findings highlight disparities in healthcare access and the need for improved primary healthcare strategies.
- Comparison with international data (USA) underscores the need for enhanced Rh disease prevention programs.