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  1. Home
  3. Kinins In Glioblastoma Microenvironment.
  1. Home
  3. Kinins In Glioblastoma Microenvironment.

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Kinins in Glioblastoma Microenvironment.

Mona N Oliveira1,2, Barbara Breznik3, Micheli M Pillat1

  • 1Department of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineus Prestes 748, São Paulo, SP, 05508-000, Brazil.

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
|August 18, 2019

View abstract on PubMed

Summary
This summary is machine-generated.

Mesenchymal stem cells interact with glioblastoma cells, influencing tumour progression. Kinin signalling, particularly through kinin receptors, plays a key role in this microenvironment and may offer new therapeutic targets.

Keywords:
Co-cultureGliomaKinin receptorsMesenchymal stem cellsMicroenvironmentTumour heterogeneity

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Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Stem Cell Biology

Background:

  • Tumour progression involves complex interactions between cancer cells, cancer stem cells, and stromal cells.
  • Mesenchymal stem cells (MSCs) can migrate to tumours and differentiate, potentially influencing tumour growth.
  • Glioblastoma (GBM) has limited therapeutic options, making MSCs a potential cell therapy tool.

Purpose of the Study:

  • To review the interactions between MSCs and glioblastoma cells within the tumour microenvironment.
  • To highlight the role of kinin signalling and kinin receptors in glioblastoma progression.
  • To explore the potential of targeting kinin signalling for glioblastoma therapy.

Main Methods:

  • Literature review of studies on MSC-glioblastoma interactions.
  • Analysis of the role of microenvironmental cues and kinin receptor signalling.
  • Examination of kinin's influence on blood-brain barrier drug transfer and angiogenesis.

    • Main Results:

    • MSCs can either inhibit or support glioblastoma progression.
    • Cancer cells exhibit differential responses to microenvironmental cues and kinin signalling.
    • Kinin receptor expression increases with glioblastoma malignancy, suggesting a significant role for kinin signalling.

    Conclusions:

    • Kinin signalling is a crucial, yet under-explored, aspect of the glioblastoma microenvironment.
    • Kinins impact drug delivery across the blood-brain barrier and tumour angiogenesis.
    • Kinin antagonists show promise as anti-invasive agents for adjuvant glioblastoma therapy.