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Behavioral phenotype and sleep problems in SATB2-associated syndrome
Allison Pierce Cotton1, Srinivasa Gokarakonda1, Aisling R Caffrey2
1Department of Child and Adolescent Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Developmental Medicine and Child Neurology
|August 18, 2019
Summary
Individuals with SATB2-associated syndrome (SAS) frequently experience behavioral issues like emotional and peer problems, alongside hyperactivity. Sleep disturbances are also common, particularly in early childhood, necessitating routine assessment and treatment.
Area of Science:
- Neuroscience
- Genetics
- Developmental Pediatrics
Background:
- SATB2-associated syndrome (SAS) is a rare genetic disorder with limited neurobehavioral data.
- Understanding behavioral phenotypes and sleep disturbances is crucial for managing SAS.
Purpose of the Study:
- To investigate the prevalence and nature of behavioral phenotypes in individuals with SAS.
- To identify the frequency and types of sleep disturbances in the SAS population.
Main Methods:
- Utilized the Strengths and Difficulties Questionnaire (SDQ) and a sleep questionnaire administered to parents of individuals with SAS.
- Compared scores from 31 SAS participants (ages 2-16) against normative data.
Main Results:
- Individuals with SAS showed significantly higher Total Difficulty scores on the SDQ compared to controls (p<0.001).
- High frequencies of emotional problems (22.6%), peer problems (48.4%), hyperactivity (48.4%), and low prosocial behavior (45.2%) were observed.
- Ten participants (5-15 years) had sleep disorders, with sleep-wake transition disorders being most common.
Conclusions:
- SAS is associated with a high risk of diverse and burdensome behavioral phenotypes and sleep difficulties.
- Sleep problems are particularly prevalent in early childhood.
- Routine screening and management for behavioral and sleep issues are recommended for individuals with SAS.
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