Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

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Emanuela Galliera1,2, Luca Massaccesi1, Elena de Vecchi2

  • 1Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

Clinical Chemistry and Laboratory Medicine
|August 18, 2019
PubMed

Insights

Presepsin (PSP) is an emerging biomarker for bacterial infections, reflecting immune cell activation. Its levels rise with infection and fall with antibiotic treatment, aiding diagnosis and management.

Area of Science:

  • Clinical diagnostics and infectious diseases
  • Biomarker discovery and validation

Background:

  • Accurate identification of bacterial infections is crucial for effective treatment and disease control.
  • Presepsin (PSP) is an emerging biomarker indicating early-stage infections.
  • PSP levels correlate with monocyte phagocytosis and immune response to pathogens.

Purpose of the Study:

  • To review the clinical applications of presepsin (PSP) as an infection biomarker.
  • To summarize the role of PSP in various clinical settings and infection types.

Main Methods:

  • Review of existing literature on presepsin (PSP) measurement and applications.
  • Analysis of PSP's diagnostic and prognostic value in different clinical fields.

Main Results:

  • Plasmatic PSP levels increase during bacterial infection and decrease following antibiotic therapy.
  • PSP serves as a marker for activated immune cell response against pathogens.
  • Various methods for PSP measurement have been developed.

Conclusions:

  • Presepsin (PSP) shows promise as an early diagnostic marker for diverse infections.
  • Its utility spans intensive care, neonatal, orthopedic, pulmonary, fungal, and cardiovascular infections.
  • PSP aids in monitoring treatment response and disease progression.
Keywords:
bacterial infectionpresepsinserum marker

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