Protocols for early discharging of premature infants: an empirical assessment on safety and savings
Related Experiment Video
Updated: Jan 20, 2026

A Within-subjects Experimental Protocol to Assess the Effects of Social Input on Infant EEG
Published on: May 3, 2017
Chiara Daicampi1, Rosanna I Comoretto2, Nicola Soriani2
1Department of Women's and Children's Health, University of Padova, Padova, Italy.
Insights
Evaluating early discharge criteria for preterm newborns reveals a trade-off between saving hospital days and ensuring infant safety. Some criteria reduce infections and costs but may miss post-discharge apnea and bradycardia episodes.
Area of Science:
- Neonatal Medicine
- Health Economics
- Pediatric Care
Background:
- Preterm newborns can be discharged when clinically stable.
- Multiple criteria for early discharge exist.
- Quantitative comparison of these criteria is lacking.
Purpose of the Study:
- To quantitatively compare the impact of seventeen early discharge criteria.
- To assess hospitalization savings, safety, and costs associated with each criterion.
Main Methods:
- Retrospective analysis of clinical histories from 213 preterm infants.
- Application of 17 literature-derived early discharge criteria.
- Computation of hospitalization savings, safety, and costs for each criterion.
Main Results:
- Average savings ranged from 1.1 to 10.3 hospital days per infant.
- Fewer infections (0.3-1.1 per infant) were observed with certain criteria.
- All criteria showed post-discharge apnea/bradycardia episodes (0.3-1.4 mean).
- Criteria saving more days demonstrated higher cost-effectiveness and infection reduction.
Conclusions:
- A clear trade-off exists between saved hospital days and infant health risks.
- Early discharge criteria impact health care costs.
- Careful consideration of criteria is needed to balance benefits and risks.
Abstract:
Background Preterm newborns may be discharged when clinical conditions are stable. Several criteria for early discharge have been proposed in the literature. This study carried out the first quantitative comparison of their impact in terms of hospitalization savings, safety and costs. Methods This study was based on the clinical histories of 213 premature infants born in the Neonatal Intensive Care Unit of Padova University Hospital between 2013 and 2014. Seventeen early discharge criteria were drawn from the literature and retrospectively applied to these data, and computation of hospitalization savings, safety and costs implied by each criterion was carried out. Results Among the criteria considered, average gains ranged from 1.1 to 10.3 hospital days and between 0.3 and 1.1 fewer infections per discharged infant. Criteria that led to saving more hospital days had higher cost-effectiveness in terms of crisis and infection, and they spared infants from more infections. However, episodes of apnea and bradycardia were detected after the potential early discharge date for all criteria, with a mean number of episodes numbering between 0.3 and 1.4. Conclusion The results highlight a clear trade-off between days saved and health risks for infants, with potential consequences for health care costs.
More Related Videos
11:50Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
Published on: January 7, 2020
07:11Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
Published on: February 5, 2019
Related Concept Videos
Discharge Summary Forms
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
Empirical Method to Interpret Standard Deviation
This rule is used widely in statistics to calculate the proportion of data values...
Survey Safety
RC Circuits: Discharging A Capacitor
Household Wiring And Electrical Safety
Drug Dosing: Infants and Children